, PhD, professor and chair of the Department of Physiology at UC San Francisco, is a winner of the .
一道本不卡免费高清Julius, 63, received the prize “for discovering molecules, cells, and mechanisms underlying pain sensation,” according to the Breakthrough Prize Foundation. He is one of four researchers honored with this year’s life sciences award.
Now in its eighth year, the Breakthrough Prize was founded by Silicon Valley pioneers Sergey Brin, Yuri and Julia Milner, Mark Zuckerberg and Priscilla Chan, and Anne Wojcicki. The annual prize recognizes “achievements in the Life Sciences, Fundamental Physics and Mathematics, disciplines that ask the biggest questions and seek the deepest explanations.” Each Breakthrough Prize includes a $3 million cash award.
一道本不卡免费高清A biochemist and molecular biologist, Julius has made great strides in deciphering what’s behind our ability to sense heat, cold and chemical irritants – work that has offered new insights to scientists who aim to better understand and treat pain. One of Julius’ drivers has been the need for new drugs that could effectively treat pain without the side effects and addictive potential of opioid drugs.
“As a scientist, you want to understand the basics,” Julius said. “Ultimately, from the therapeutic perspective, identifying signaling molecules within pain pathways has relevance for drug design, because those are potential targets for the development of new treatments.”
Julius has also applied these approaches to identify the molecular source of the icy sensation triggered by menthol from mint. Just as heat acts on TRPV1 similarly to capsaicin, Julius’ lab found that a related channel called TRPM8 can be activated either by menthol or by cold temperatures. A third TRP channel, TRPA1, responds to the pungent compounds that give wasabi its punch, and is also involved in inflammatory pain. In 2015, Julius and Cheng used cryo-EM to determine the structure of this “wasabi receptor.”
Julius and his fellow awardees will be recognized at the eighth annual Breakthrough Prize gala awards ceremony on Sunday, Nov. 3, at NASA Ames Research Center in Mountain View, Calif., which will be broadcast live on the National Geographic channel. The awards will be followed by the on Monday, Nov. 4. The symposium is being hosted at UCSF’s Mission Bay campus.
Julius, the Morris Herzstein Chair in Molecular Biology and Medicine at UCSF, has received numerous honors and awards, including the Canada Gairdner International Award, the Shaw Prize in Life Science and Medicine, the Dr. Paul Janssen Award for Biomedical Research, the Passano Award, the Prince of Asturias Award for Technical and Scientific Research, the Scolnick Prize from the McGovern Institute for Brain Research, the Unilever Science Prize, and the Klaus Joachim Zülch Neuroscience Prize. He is a member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences.
The University of California, San Francisco (UCSF) is exclusively focused on the health sciences and is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. , which serves as UCSF’s primary academic medical center, includes and other clinical programs, and has affiliations throughout the Bay Area.